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What is Galliprant for Dogs?

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What is Galliprant for Dogs?

Prescription Treatment for Osteoarthritis in Dogs

Senior Dog older canine

What is galliprant? Galliprant Grapiprant Tablets for Dogs

In March of 2016, galliprant was approved by the FDA as the newest prescription medication for dogs approved to treat the pain and inflammation from osteoarthritis. Galliprant belongs to a category of drugs called non steroidal anti-inflammatory drugs or NSAIDs. Galliprant, active ingredient grapiprant, comes in a flavored chewable tablet form and is best absorbed by the body when given to a dog on an empty stomach (60 minutes+ before next meal time). However, if a dog experiences nausea when taking alone, it can also be taken with food.

Galliprant works quickly as an anti inflammatory agent to relieve the pain and swelling caused by osteoarthritis; most doggies show reduced pain symptoms within 1 to 2 hours. Galliprant has a long half-life and one dose each day should be sufficient for osteoarthritis pain and inflammation.

Treating Osteoarthritis in Dogs

Canine osteoarthritis (OA) is a chronic medical condition where cartilage deteriorates and causes two or more bones to painfully rub against each other. This uncomfortable rubbing can cause permanent damage to the affected joint as well as irritation, pain, inflammation, and debility. Senior dogs as well as overweight dogs have a higher risk of developing OA.

Inflammation is the body's natural response to injury or irritation. When cells are damaged, the body releases an enzyme called cyclooxygenase, which then stimulates the cell to produce substances called prostaglandins. These prostaglandins are what cause the common signs of inflammation like pain, swelling, fever, and redness. The scientific name for this process is the Inflammatory Pathway. 

The FDA had previously approved several other NSAIDs for osteoarthritis pain and inflammation in dogs, but galliprant is the first of its kind in terms of its specific targeted action. While previous anti inflammatory drugs used in dogs work by blocking COX, galliprant provides targeted osteoarthritis pain relief further along the inflammatory pathway by blocking the activity of a specific prostaglandin.

Galliprant Side Effects for Dogs

When used for treating canine osteoarthritis pain, galliprant is known to cause these common adverse reactions: 

  • Vomiting
  • Diarrhea 
  • Decreased appetite and tiredness
  • Changes in urination frequency or smell
  • Change in stool (consistency, presence of blood or mucus)
  • Jaundice (yellowing of gums/eyes/skin)
  • Changes in behavior (aggression, depression, etc)

Signs of more serious galliprant side effects include:

  • Gastrointestinal Ulcers
  • Stomach/Intestinal bleeding
  • Liver and kidney toxicity
  • Neurological side effects, including seizures

Pairing galliprant with another NSAID or a steroid medication like prednisone increases the risk of these side effects. Contact your veterinarian immediately if your pet is experiencing galliprant side effects.

Other Non Steroidal Anti Inflammatory Treatments

FDA approved alternative to galliprant include the following non steroidal anti inflammatory drug medictations below:

Active Ingredient

Brand Names


Marketed under multiple trade names


Deramaxx, Doxidyl






Marketed under multiple trade names


A high quality joint supplement with ingredients like glucosamine, turmeric, collagen, and green lipped mussels. can help provide connective tissue support and help support healthy bone, joint and hip function in your dog.

Canines Who Should Avoid Galliprant

There are times when galliprant is not the right treatment for your dog’s pain and inflammation associated with osteoarthritis. Galliprant has only been studied and approved by the FDA for use in dogs older than 9 months of age and who weigh at least 8 pounds. Dogs younger than 9 months should not take galliprant. Because galliprant is dosed by weight as 2mg/kg, any dog less than 8 lbs (3.6kg) is not able to be dosed correctly. Additionally this medication is not approved for use in pregnant or lactating dogs. Any dog with prior kidney, liver, or heart disease is more likely to experience adverse effects. Some pups may be allergic to grapiprant, so another anti inflammatory drug NSAIDs or corticosteroids may be a safer option.

Supporting the Safe Use of Galliprant

Osteoarthritis in dogs is a long-term chronic condition, so a dog may be on galliprant for an extended time period. Before starting this medication, your veterinarian will want to perform baseline blood tests to gather information about your dog’s kidney and liver health. Once  grapiprant treatment begins, ongoing monitoring is recommended if used long term to make sure that the benefits of this medication treatment of canine osteoarthritis pain continues to outweigh the risks. 

Your dog should always take the lowest dose that provides adequate pain management. Owners should always consult with a veterinarian before changing the dosage. You should use galliprant to treat your dog exactly as prescribed -- this should be one daily use dosage between 20 mg and 100 mg. 100mg is the largest recommended dose for large dogs up to 150lbs. Galliprant can be potentially harmful if your dog takes too much. Galliprant is not safe for human consumption, so keep this medication out of reach of pets and children. If you think your dog may have overdosed on grapiprant, contact your vet ASAP.